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Protective effects of nicotine on gamma-aminobutyric acid neurons and dopaminergic neurons in mice with

Lei FU MD , Dezheng GONG BM , Yan PENG , Dongmei WANG BM , Hong XU , Yue LI MD , Dengqin YU BS , Yanhui FENG MD , Shengming YIN PhD , Jin GONG , Yiping SUN PhD ,

《医学前沿（英文）》 2009年 第3卷 第3期   页码 330-335 doi: 10.1007/s11684-009-0051-4

摘要： This study aimed to investigate the protective effect of nicotine on dopaminergic neurons and its mechanisms in mice with Parkinson disease (PD) induced by 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine (MPTP). C57BL/6J mice were injected with MPTP for 8 days to establish a PD model. Nicotine was given for 10 days in the nicotine therapeutic group. Animals were examined behaviorally with the pole test and traction test. Tyrosine hydroxylase (TH) and γ-aminobutyric acid (GABA) were determined by using the immunocytochemistry (ICC) method. The ultrastructural changes of the caudate nucleus (CN) were observed under electron microscopy. The results showed that pretreatment with nicotine could improve the dyskinesia of PD mice markedly. Simultaneously, TH-positive ( < 0.01) neurons and GABA-positive ( < 0.05) neurons in the nicotine therapeutic group were significantly more than those in the model group. The ultrastructural injury of the nicotine therapeutic group was also ameliorated. Nicotine has protective effects on the γ-aminobutyric acid neurons and dopaminergic neurons in the MPTP-treated mice.

关键词： Parkinson disease     nicotine     dopaminergic neuron     gamma-aminobutyric acid neuron    

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一种新型生物材料——玉米醇溶蛋白多孔支架的质量监控

张玥, 李伟迎, 兰润, 王瑾晔

《工程（英文）》 2017年 第3卷 第1期   页码 130-135 doi: 10.1016/J.ENG.2017.01.001

摘要： 我们用SDS-PAGE 研究了三种灭菌方式对玉米醇溶蛋白多孔支架的影响，并比较了在不同&gamma; 射线剂量下SDS-PAGE 图谱的变化。我们发现在剂量20~30 kGy 范围内，&gamma; 射线灭菌过程中玉米醇溶蛋白的肽链没有发生断裂或聚合，这表明&gamma; 射线灭菌对于玉米醇溶蛋白多孔支架是适用的。

关键词： 玉米醇溶蛋白     氨基酸分析     十二烷基硫酸钠&ndash     聚丙烯酰氨凝胶电泳     &gamma     射线灭菌     MTT 实验     CCK-8 实验    

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Application of gamma-ray attenuation technology in density measurement of a slurry reactor

Jian XU, Weisheng WEI, Kai ZHANG

《化学科学与工程前沿（英文）》 2010年 第4卷 第4期   页码 486-490 doi: 10.1007/s11705-010-0509-6

摘要： Axial density profile of the gas-liquid-solid mixture in a slurry bubble column was measured by gamma-ray attenuation technology. Several measures for improving measurement precision were presented based on the discussion on attenuation law. It was found that the response frequency and the ray intensity should be as high as possible to improve the measurement precision. The mass absorption coefficient depended on not the object’s thickness but the location where the object was placed between the ray source and the detector. The results showed that the density in the column decreases with the increase of column height, which indicates that the measurement by gamma-ray attenuation is reasonable.

关键词： slurry reactor     axial density distribution     gamma-ray attenuation technology    

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脉冲中子、伽马探测系统性能表征与设计技术

欧阳晓平

《中国工程科学》 2009年 第11卷 第5期   页码 44-53

摘要：

探测系统是获取辐射场特征信息的核心器件，是实施脉冲辐射探测的关键和技术基础，其性能直接决定测试数据的质量和测试方法的选择。对影响脉冲辐射探测的性能指标进行系统描述、表征是探测系统设计、研制、实际应用和综合性能评价的基础。用于复杂能谱脉冲中子、伽马混合辐射场时间谱、强度谱测量的探测系统，主要性能包括探测灵敏度、时间响应、能量响应、线性电流和中子、伽马分辨能力等指标参数，这些参数的获得与实现，需要根据中子、伽马射线与物质相互作用的基本原理，构建相应的探测结构和技术原理。在设计上，综合权衡能量收集和电荷收集方式选择、几何效率完备和高信噪比结合、信号响应和直照响应分离、探测效率与时间特性兼顾、综合性能与使用可靠性一致等设计原则，综合应用这些原则构成了探测系统设计方法。

关键词： 中子、伽马混合场     脉冲辐射探测     探测系统     设计原理     性能参数    

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一类新的光电神经元模型及其动力学 Research Articles

刘勇1,徐万江1,马军2,3,Faris ALZAHRANI4,Aatef HOBINY4

《信息与电子工程前沿（英文）》 2020年 第21卷 第9期   页码 1387-1396 doi: 10.1631/FITEE.1900606

摘要： 生物神经元可感知多种外界刺激信号，这些信号可被转化为等效的电流来驱动神经元。因此，神经元的膜电位可通过外刺激调控呈现各类放电模式。实际上，可靠的神经元模型应考虑内在的生物物理效应以及功能性编码。一个重要且有趣的问题是弄清外界信号转录过程的物理机制。外界信号通常被转化为等效的跨膜电流或信号源以诱发动作电位。提出一个光电神经元模型以表达其非线性编码过程和外界光信号驱动神经元的电活动响应。在该模型中，使用一个光电管激活一个简单的FitzHugh-Nagumo（FHN）神经元电路，并施加外界光信号（光照）于光电管产生时变电流源或电压源以驱动神经元电路。这种光电管耦合的神经元电路能探测和感知外界光信号，其作用类似于人工电子眼。通过分岔详细分析神经元模态迁移和放电斑图特征。通过调制神经元电路的光电流，神经元膜电位序列可呈现静息态、尖峰放电、簇放电和混沌特征。这些结果可为进一步研究神经动力学和神经电路提供参考。

关键词： 光电神经元；神经元模型；分岔；簇放电；光电管    

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Use of gamma-irradiation pretreatment for enhancement of anaerobic digestibility of sewage sludge

YUAN Shoujun, ZHENG Zheng, YU Xin, ZHAO Yongfu, MU Yanyan

《环境科学与工程前沿（英文）》 2008年 第2卷 第2期   页码 247-250 doi: 10.1007/s11783-008-0041-9

摘要： The effects of ?-irradiation pretreatment on anaerobic digestibility of sewage sludge was investigated in this paper. Parameters like solid components, soluble components, and biogas production of anaerobic digestion experiment for sewage sludge were measured. The values of these parameters were compared before and after ?-irradiation pretreatment. Total solid (TS), volatile solid (VS), suspended solid (SS), volatile suspended solid (VSS), and average floc size of samples decreased after ?-irradiation treatment. Besides, floc size distribution of sewage sludge shifted from 80–100 ?m to 0–40 ?m after ?-irradiation treatment at the doses from 0 to 30 kGy, which indicated the disintegration of sewage sludge. Moreover, microbe cells of sewage sludge were ruptured by ?-irradiation treatment, which resulted in the release of cytoplasm and increase of soluble chemical oxygen demand (SCOD). Both sludge disintegration and microbe cells rupture enhanced the subsequent anaerobic digestion process, which was demonstrated by the increase of accumulated biogas production. Compared with digesters fed with none irradiated sludge, the accumulated biogas production increased 44, 98, and 178 mL for digesters fed sludge irradiated at 2.48, 6.51, and 11.24 kGy, respectively. The results indicated that ?-irradiation pretreatment could effectively enhance anaerobic digestibility of sewage sludge, and correspondingly, could accelerate hydrolysis process, shorten sludge retention time of sludge anaerobic digestion process.

关键词： anaerobic digestibility     soluble chemical     cytoplasm     digestion process     soluble    

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用于16.7 MeV脉冲高能γ探测的散射吸收方法研究

谭新建,欧阳晓平,王群书

《中国工程科学》 2009年 第11卷 第8期   页码 48-51

摘要：

理论分析计算的基础上，提出了基于康普顿效应的散射吸收探测方法，该方法能实现高低能&gamma;灵敏度比值达106～108，且对高能&gamma;灵敏度较大，为10-21～10-16 C·cm2，其性能指标在一定程度上优于目前使用的基于磁分析器与Cherenkov探测器的高能&gamma;探测方法指标。

关键词： 高能γ     切伦柯夫探测器     散射吸收法    

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单萜类化合物芳樟醇、甲基丁香酚、草蒿脑和香茅醛对配体门控离子通道的作用模式 Article

Amy S. Li, Akimasa Iijima, Junhao Huang, Qing X. Li, Yongli Chen

《工程（英文）》 2020年 第6卷 第5期   页码 541-545 doi: 10.1016/j.eng.2019.07.027

摘要： 众所周知，&gamma;-氨基丁酸A型受体（GABAAR）和烟碱型乙酰胆碱受体（nAChR）是目前市场上使用的合成杀虫剂的主要分子靶标。LL是GABAAR的一种浓度依赖性、非竞争性抑制剂，因为在实验中我们发现，小鼠α1β3&gamma;2L GABAAR的&gamma;-氨基丁酸（GABA）半最大效应浓度（EC50

关键词： 精油     γ-氨基丁酸A型受体     芳樟醇     单萜     烟碱型乙酰胆碱受体    

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Sulfonic acid-functionalized mesoporous silica catalyst with different morphology for biodiesel production

《化学科学与工程前沿（英文）》 2022年 第16卷 第8期   页码 1198-1210 doi: 10.1007/s11705-021-2133-z

摘要： Sulfonic acid functionalized mesoporous silica based solid acid catalysts with different morphology were designed and fabricated. The synthesized materials were characterized by various physicochemical and spectroscopic techniques like scanning electron microscope-energy dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy, Brunauer–Emmett–Teller surface area, thermogravimetric analysis and n-butylamine acidity. The shape of catalysts particles plays an important role in its activity. The sulfonic acid functionalized mesoporous silica catalysts of spherical shape and the cube shape were assessed for catalytic activity in biodiesel production. The catalytic biodiesel production reaction over the catalysts were studied by esterification of free fatty acid, oleic acid with methanol. The effect of various reaction parameters such as catalyst concentration, acid/alcohol molar ratio, catalyst amount, reaction temperature and reaction time on catalytic activity were investigated to optimize the conditions for maximum conversion. It was sulfonated cubic shape mesoporous silica which exhibited better activity as compared to the spherical shape silica catalysts. Additionally, the catalyst was regenerated and reused up to three cycles without any significant loss in activity. The present catalysts exhibit superior performance in biodiesel production and it can be used for the several biodiesel feedstock’s that are rich in free fatty acids.

关键词： solid acid catalyst     mesoporous silica     sulfonic acid     biodiesel     esterification     oleic acid    

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Statistical modeling of radiolytic (

G. S. Muthu Iswarya, B. Nirkayani, A. Kavithakani, V. C. Padmanaban

《环境科学与工程前沿（英文）》 2019年 第13卷 第3期 doi: 10.1007/s11783-019-1126-3

摘要：

Linear, interactive and quadratic effects of process parameters were studied.

Degradation of Ofloxacin (Ofx) was related with G value of irradiation process.

The synergistic effect of H2O2 on lower dose of g-irradiation was established.

The process follows pseudo first order with dose constant (d = 0.232 kGy–1).

关键词： Ofloxacin     Gamma irradiation     Face centered central composite design     Reaction kinetics     Gas Chromatography-Mass spectrum    

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Amino acid promoted hydrogen battery system using Mn-pincer complex for reversible CO hydrogenation toformic acid

《能源前沿（英文）》 2022年 第16卷 第5期   页码 697-699 doi: 10.1007/s11708-022-0843-7

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Enzyme@bismuth-ellagic acid: a versatile platform for enzyme immobilization with enhanced acid-base stability

《化学科学与工程前沿（英文）》 2023年 第17卷 第6期   页码 784-794 doi: 10.1007/s11705-022-2278-4

摘要： In situ encapsulation is an effective way to synthesize enzyme@metal–organic framework biocatalysts; however, it is limited by the conditions of metal–organic framework synthesis and its acid-base stability. Herein, a biocatalytic platform with improved acid-base stability was constructed via a one-pot method using bismuth-ellagic acid as the carrier. Bismuth-ellagic acid is a green phenol-based metal–organic framework whose organic precursor is extracted from natural plants. After encapsulation, the stability, especially the acid-base stability, of amyloglucosidases@bismuth-ellagic acid was enhanced, which remained stable over a wide pH range (2–12) and achieved multiple recycling. By selecting a suitable buffer, bismuth-ellagic acid can encapsulate different types of enzymes and enable interactions between the encapsulated enzymes and cofactors, as well as between multiple enzymes. The green precursor, simple and convenient preparation process provided a versatile strategy for enzymes encapsulation.

关键词： bismuth-ellagic acid     in situ encapsulation     enzyme@MOF biocomposites    

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Discovery of novel ursolic acid derivatives as effective antimicrobial agents through a ROS-mediated

《化学科学与工程前沿（英文）》 2023年 第17卷 第12期   页码 2101-2113 doi: 10.1007/s11705-023-2361-5

摘要： In response to the reduction of food production and economic losses caused by plant bacterial diseases, it is necessary to develop new, efficient, and green pesticides. Natural products are rich and sustainable source for the development of new pesticides due to their low toxicity, easy degradation, and eco-friendliness. In this study, we prepared three series of ursolic acid derivatives and assessed their antibacterial ability. Most target compounds exhibited outstanding antibacterial activities. Among them, the relative optimal EC50 values of Xanthomonas oryzae pv. oryzae and Xanthomonas axonopodis pv. citri were 2.23 (A17) and 1.39 (A16) μg·mL–1, respectively. The antimicrobial mechanism showed that compound A17 induced an excessive accumulation and production of reactive oxygen species in bacteria and damaged the cell membrane integrity to kill bacteria. More interestingly, the addition of low concentrations of exogenous hydrogen peroxide enhanced the antibacterial efficacy of compound A17 against Xanthomonas oryzae pv. oryzae. These entertaining results suggested that compound A17 induced an apparent apoptotic behavior in the tested bacteria. Overall, we developed the promising antimicrobial agents that destroyed the redox system of phytopathogenic bacteria, further demonstrating the unprecedented potential of ursolic acid for agricultural applications.

关键词： ursolic acid     antibacterial activities     reactive oxygen species     apoptosis    

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Synergistic scale inhibition of polyaspartic acid composite with magnetic field

LIU Zhenfa, WANG Yanji, GAO Yuhua, ZHANG Lihui

《化学科学与工程前沿（英文）》 2007年 第1卷 第3期   页码 261-265 doi: 10.1007/s11705-007-0047-z

摘要： Polyaspartic acid (PASP) composite, a scale inhibitor, was prepared from PASP, itaconic acid–acrylic acid–acrylic ester (IA-AA-AE) terpolymer and 2-phosphonobutane- 1,2,4-tricarboxylic acid (PBTCA). The scale inhibition of PASP composite and the effect of its synergism with a magnetic field on scale inhibition were investigated. Calcium carbonate crystals in scale samples were characterized by means of SEM and XRD. The static and dynamic experiments show that the chelating function of PASP composite for Ca can be enhanced by synergism with a magnetic field. Under Ca 650 mg/L, HCO 1,300 mg/L and PASP composite 4 mg/L, the scale inhibition rate of PASP composite in magnetic water can increase by 10% in static state and by 20% in dynamic experiments. Scanning electron microscope (SEM) and X-ray diffraction (XRD) results show that calcite and aragonite can be completely transformed into vaterite by using PASP composite.

关键词： synergism     magnetic     PBTCA     dynamic     acid–acrylic acid–acrylic    

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Abiotic association of phthalic acid esters with humic acid of a sludge landfill

Xiaoli CHAI, Yongxia HAO, Xin ZHAO, Guixiang LIU, Ying ZHU, Rong JI, Jun WU, Huanhuan TONG, Youcai ZHAO

《环境科学与工程前沿（英文）》 2012年 第6卷 第6期   页码 778-783 doi: 10.1007/s11783-012-0434-7

摘要： The abiotic association between phthalic acid esters (PAEs) and humic substances (HS) in sludge landfill plays an important role in the fate and stability of PAEs. An equilibrium dialysis combined with C-labeling was used to study the abiotic association of two abundant PAEs (diethyl phthalate and di- -butyl phthalate) with humic acid (HA) isolated from a sludge landfill with different stabilization times and different molecular weights. Elemental analysis and Fourier Transform Infrared Spectrophotometer (FTIR) suggested that high value of HA was related to the high aromatic content and large molecular weight of HA. The results indicated that the association strength of PAEs with HA depended on both the properties of the PAEs and the characteristics of HA. The values of the association were strongly dependent on solution pH, and decreased dramatically as the pH was increased from 3.0 to 9.0. The results suggested that non-specific hydrophobic interaction between PAEs and HA was the main contributor to the association of the PAEs with HA. The interactive hydrogen-bonds between the HA and the PAEs molecules may also be involved in the association.

关键词： abiotic association     phthalic acid esters (PAEs)     humic acid     sludge     landfill    

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标题 作者 时间 类型 操作

Protective effects of nicotine on gamma-aminobutyric acid neurons and dopaminergic neurons in mice with

Lei FU MD , Dezheng GONG BM , Yan PENG , Dongmei WANG BM , Hong XU , Yue LI MD , Dengqin YU BS , Yanhui FENG MD , Shengming YIN PhD , Jin GONG , Yiping SUN PhD ,

期刊论文

一种新型生物材料——玉米醇溶蛋白多孔支架的质量监控

张玥, 李伟迎, 兰润, 王瑾晔

期刊论文

Application of gamma-ray attenuation technology in density measurement of a slurry reactor

Jian XU, Weisheng WEI, Kai ZHANG

期刊论文

脉冲中子、伽马探测系统性能表征与设计技术

欧阳晓平

期刊论文

一类新的光电神经元模型及其动力学

刘勇1,徐万江1,马军2,3,Faris ALZAHRANI4,Aatef HOBINY4

期刊论文

Use of gamma-irradiation pretreatment for enhancement of anaerobic digestibility of sewage sludge

YUAN Shoujun, ZHENG Zheng, YU Xin, ZHAO Yongfu, MU Yanyan

期刊论文

用于16.7 MeV脉冲高能γ探测的散射吸收方法研究

谭新建,欧阳晓平,王群书

期刊论文

单萜类化合物芳樟醇、甲基丁香酚、草蒿脑和香茅醛对配体门控离子通道的作用模式

Amy S. Li, Akimasa Iijima, Junhao Huang, Qing X. Li, Yongli Chen

期刊论文

Sulfonic acid-functionalized mesoporous silica catalyst with different morphology for biodiesel production

期刊论文

Statistical modeling of radiolytic (

G. S. Muthu Iswarya, B. Nirkayani, A. Kavithakani, V. C. Padmanaban

期刊论文

Amino acid promoted hydrogen battery system using Mn-pincer complex for reversible CO hydrogenation toformic acid

期刊论文

Enzyme@bismuth-ellagic acid: a versatile platform for enzyme immobilization with enhanced acid-base stability

期刊论文

Discovery of novel ursolic acid derivatives as effective antimicrobial agents through a ROS-mediated

期刊论文

Synergistic scale inhibition of polyaspartic acid composite with magnetic field

LIU Zhenfa, WANG Yanji, GAO Yuhua, ZHANG Lihui

期刊论文

Abiotic association of phthalic acid esters with humic acid of a sludge landfill

Xiaoli CHAI, Yongxia HAO, Xin ZHAO, Guixiang LIU, Ying ZHU, Rong JI, Jun WU, Huanhuan TONG, Youcai ZHAO

期刊论文